Heart Rate and Risk of Cancer Death in Healthy Men
Identifieur interne : 006128 ( Main/Exploration ); précédent : 006127; suivant : 006129Heart Rate and Risk of Cancer Death in Healthy Men
Auteurs : Xavier Jouven [France] ; Sylvie Escolano [France] ; David Celermajer [Australie] ; Jean-Philippe Empana [France] ; Annie Bingham [France] ; Olivier Hermine [France] ; Michel Desnos [France] ; Marie-Cécile Perier [France] ; Eloi Marijon [France] ; Pierre Ducimetière [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2011.
Abstract
Data from several previous studies examining heart-rate and cardiovascular risk have hinted at a possible relationship between heart-rate and non-cardiac mortality. We thus systematically examined the predictive value of heart-rate variables on the subsequent risk of death from cancer.
In the Paris Prospective Study I, 6101 asymptomatic French working men aged 42 to 53 years, free of clinically detectable cardiovascular disease and cancer, underwent a standardized graded exercise test between 1967 and 1972. Resting heart-rate, heart-rate increase during exercise, and decrease during recovery were measured. Change in resting heart-rate over 5 years was also available in 5139 men. Mortality including 758 cancer deaths was assessed over the 25 years of follow-up.
There were strong, graded and significant relationships between all heart-rate parameters and subsequent cancer deaths. After adjustment for age and tobacco consumption and, compared with the lowest quartile, those with the highest quartile for resting heart-rate had a relative risk of 2.4 for cancer deaths (95% confidence interval: 1.9–2.9, p<0.0001) This was similar after adjustment for traditional cardiovascular risk factors and was observed for the commonest malignancies (respiratory and gastrointestinal). Similarly, significant relationships with cancer death were observed between poor heart rate increase during exercise, poor decrease during recovery and greater heart-rate increase over time (p<0.0001 for all).
Resting and exercise heart rate had consistent, graded and highly significant associations with subsequent cancer mortality in men.
Url:
DOI: 10.1371/journal.pone.0021310
PubMed: 21826196
PubMed Central: 3149594
Affiliations:
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Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP HEGP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Escolano, Sylvie" sort="Escolano, Sylvie" uniqKey="Escolano S" first="Sylvie" last="Escolano">Sylvie Escolano</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INSERM PARCC University Paris Descartes UMR-S970, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM PARCC University Paris Descartes UMR-S970, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Celermajer, David" sort="Celermajer, David" uniqKey="Celermajer D" first="David" last="Celermajer">David Celermajer</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Sydney Medical School, University of Sydney, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Empana, Jean Philippe" sort="Empana, Jean Philippe" uniqKey="Empana J" first="Jean-Philippe" last="Empana">Jean-Philippe Empana</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INSERM PARCC University Paris Descartes UMR-S970, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM PARCC University Paris Descartes UMR-S970, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bingham, Annie" sort="Bingham, Annie" uniqKey="Bingham A" first="Annie" last="Bingham">Annie Bingham</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INSERM PARCC University Paris Descartes UMR-S970, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM PARCC University Paris Descartes UMR-S970, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hermine, Olivier" sort="Hermine, Olivier" uniqKey="Hermine O" first="Olivier" last="Hermine">Olivier Hermine</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Department of Adult Hematology CNRS UMR 8147, Hopital Necker Enfants-Malades, University Paris Descartes, AP-HP, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Adult Hematology CNRS UMR 8147, Hopital Necker Enfants-Malades, University Paris Descartes, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Desnos, Michel" sort="Desnos, Michel" uniqKey="Desnos M" first="Michel" last="Desnos">Michel Desnos</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>AP-HP, HEGP, Department of Cardiology, University Paris V, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, HEGP, Department of Cardiology, University Paris V, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Perier, Marie Cecile" sort="Perier, Marie Cecile" uniqKey="Perier M" first="Marie-Cécile" last="Perier">Marie-Cécile Perier</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INSERM PARCC University Paris Descartes UMR-S970, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM PARCC University Paris Descartes UMR-S970, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marijon, Eloi" sort="Marijon, Eloi" uniqKey="Marijon E" first="Eloi" last="Marijon">Eloi Marijon</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INSERM PARCC University Paris Descartes UMR-S970, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM PARCC University Paris Descartes UMR-S970, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>AP-HP HEGP, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP HEGP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ducimetiere, Pierre" sort="Ducimetiere, Pierre" uniqKey="Ducimetiere P" first="Pierre" last="Ducimetière">Pierre Ducimetière</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>IFR 69, INSERM, Université Paris Sud-XI, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>IFR 69, INSERM, Université Paris Sud-XI, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Data from several previous studies examining heart-rate and cardiovascular risk have hinted at a possible relationship between heart-rate and non-cardiac mortality. We thus systematically examined the predictive value of heart-rate variables on the subsequent risk of death from cancer.</p></sec><sec><title>Methods</title><p>In the Paris Prospective Study I, 6101 asymptomatic French working men aged 42 to 53 years, free of clinically detectable cardiovascular disease and cancer, underwent a standardized graded exercise test between 1967 and 1972. Resting heart-rate, heart-rate increase during exercise, and decrease during recovery were measured. Change in resting heart-rate over 5 years was also available in 5139 men. Mortality including 758 cancer deaths was assessed over the 25 years of follow-up.</p></sec><sec><title>Findings</title><p>There were strong, graded and significant relationships between all heart-rate parameters and subsequent cancer deaths. After adjustment for age and tobacco consumption and, compared with the lowest quartile, those with the highest quartile for resting heart-rate had a relative risk of 2.4 for cancer deaths (95% confidence interval: 1.9–2.9, p<0.0001) This was similar after adjustment for traditional cardiovascular risk factors and was observed for the commonest malignancies (respiratory and gastrointestinal). Similarly, significant relationships with cancer death were observed between poor heart rate increase during exercise, poor decrease during recovery and greater heart-rate increase over time (p<0.0001 for all).</p></sec><sec><title>Interpretation</title><p>Resting and exercise heart rate had consistent, graded and highly significant associations with subsequent cancer mortality in men.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dyer, Ar" uniqKey="Dyer A">AR Dyer</name></author><author><name sortKey="Persky, V" uniqKey="Persky V">V Persky</name></author><author><name sortKey="Stamler, J" uniqKey="Stamler J">J Stamler</name></author><author><name sortKey="Oglesby, P" uniqKey="Oglesby P">P Oglesby</name></author><author><name sortKey="Shekelle, Rb" uniqKey="Shekelle R">RB Shekelle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kannel, Wb" uniqKey="Kannel W">WB 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Thun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epel, E" uniqKey="Epel E">E Epel</name></author><author><name sortKey="Blackburn, E" uniqKey="Blackburn E">E Blackburn</name></author><author><name sortKey="Jin, J" uniqKey="Jin J">J Jin</name></author><author><name sortKey="Dhabar, F" uniqKey="Dhabar F">F Dhabar</name></author><author><name sortKey="Adler N Et, Al" uniqKey="Adler N Et A">al Adler N et</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Pj" uniqKey="Schwartz P">PJ Schwartz</name></author><author><name sortKey="Vanoli, E" uniqKey="Vanoli E">E Vanoli</name></author><author><name sortKey="Stramba Badiale, M" uniqKey="Stramba Badiale M">M Stramba-Badiale</name></author><author><name sortKey="De Ferrari, Gm" uniqKey="De Ferrari G">GM De Ferrari</name></author><author><name sortKey="Billman Ge Et, Al" uniqKey="Billman Ge Et A">al Billman GE et</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Jouven, Xavier" sort="Jouven, Xavier" uniqKey="Jouven X" first="Xavier" last="Jouven">Xavier Jouven</name></region><name sortKey="Bingham, Annie" sort="Bingham, Annie" uniqKey="Bingham A" first="Annie" last="Bingham">Annie Bingham</name><name sortKey="Desnos, Michel" sort="Desnos, Michel" uniqKey="Desnos M" first="Michel" last="Desnos">Michel Desnos</name><name sortKey="Ducimetiere, Pierre" sort="Ducimetiere, Pierre" uniqKey="Ducimetiere P" first="Pierre" last="Ducimetière">Pierre Ducimetière</name><name sortKey="Empana, Jean Philippe" sort="Empana, Jean Philippe" uniqKey="Empana J" first="Jean-Philippe" last="Empana">Jean-Philippe Empana</name><name sortKey="Escolano, Sylvie" sort="Escolano, Sylvie" uniqKey="Escolano S" first="Sylvie" last="Escolano">Sylvie Escolano</name><name sortKey="Hermine, Olivier" sort="Hermine, Olivier" uniqKey="Hermine O" first="Olivier" last="Hermine">Olivier Hermine</name><name sortKey="Jouven, Xavier" sort="Jouven, Xavier" uniqKey="Jouven X" first="Xavier" last="Jouven">Xavier Jouven</name><name sortKey="Marijon, Eloi" sort="Marijon, Eloi" uniqKey="Marijon E" first="Eloi" last="Marijon">Eloi Marijon</name><name sortKey="Marijon, Eloi" sort="Marijon, Eloi" uniqKey="Marijon E" first="Eloi" last="Marijon">Eloi Marijon</name><name sortKey="Perier, Marie Cecile" sort="Perier, Marie Cecile" uniqKey="Perier M" first="Marie-Cécile" last="Perier">Marie-Cécile Perier</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Celermajer, David" sort="Celermajer, David" uniqKey="Celermajer D" first="David" 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